2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-118802
    4-Hydroxy DPT 63065-88-3 98%
    4-Hydroxy DPT is a tryptamine that induces the head-twitch response (HTR) in mice.
    4-Hydroxy DPT
  • HY-118825
    N-butyl Amphetamine hydrochloride 35892-11-6 98%
    N-butyl Amphetamine hydrochloride is an Amphetamine analog, which can be used in forensic applications.
    N-butyl Amphetamine hydrochloride
  • HY-118974
    PD-151307 225925-12-2 98%
    PD-151307 is an N-type calcium channel antagonist with significant inhibitory effects in IMR-32 human neuroblastoma cells, exhibiting an IC50 of 0.32 µM. PD-151307 can be used in research related to cancer therapy, anticonvulsants, and neuropathic pain.
    PD-151307
  • HY-118987
    AT-127 2099680-72-3 98%
    AT-127 is a NOP receptor partial agonist, stimulating NOP/G-protein interaction in a concentration dependent manner.
    AT-127
  • HY-118997
    PD-89211 444725-49-9 98%
    PD-89211 is a selective dopamine D4 receptor antagonist with a Ki value of 3.7 nM. PD-89211 reverses Quinpirole (HY-B1752A)-induced [3H]thymidine uptake in CHOpro5 cells (IC50 = 2.1 nM). PD-89211 regulates dopamine/norepinephrine metabolism in the hippocampus and can be used for research on central nervous system disorders such as schizophrenia.
    PD-89211
  • HY-119076
    A31472 69319-52-4 98%
    A31472 is a dopamine D-2 receptors antagonist that is promising for research of antipsychotic agents.
    A31472
  • HY-119183
    A 23887 61955-05-3 98%
    A 23887 is a semirigid antipsychotic compound with considerable affinity for dopamine D2 receptor.
    A 23887
  • HY-119191
    KF26777 free base 206129-88-6 98%
    KF26777 (free base) is a potent and selective adenosine A3 receptor antagonist with an Ki value of 0.2 nM and possesses 9000-, 2350- and 3100-fold selectivity against adenosine A1, A2A and A2B receptors, respectively. KF26777 (free base) potently inhibits the [125I]AB-MECA binding to adenosine A3 receptors. KF26777 (free base) is promising for research of brain ischemia and inflammatory disease including asthma.
    KF26777 free base
  • HY-119221
    AUY954 820240-77-5 98%
    AUY954 is an oral active and selective sphingosine-1-phosphate receptor 1 agonist with the EC50 values of 1.2 nM, 0.9 nM >10,000 nM, 1,210 nM, >1,000 nM, and 340 nM for hS1P2, mS1P2, S1P2, S1P3, S1P4, and S1P5 receptors, respectively. AUY954 can be used for study of experimental autoimmune neuritis.
    AUY954
  • HY-119223
    Desmethylmirtazapine 61337-68-6 98%
    Desmethylmirtazapine is an active metabolite of Mirtazapine that has antidepressant effects.
    Desmethylmirtazapine
  • HY-119224
    BIA 3-335 359783-06-5 98%
    BIA 3-335 is an inhibitor for catechol-O-methyltransferase (COMT), and can be used in research about Parkinson's disease.
    BIA 3-335
  • HY-119333
    NNC 11-1607 250649-13-9 98%
    NNC 11-1607 is a selective M1/M4 muscarinic acetylcholine receptor (mAChR) agonist. NNC 11-1607 inhibits Forskolin (HY-15371)-stimulated cAMP accumulation in Chinese hamster ovary cells expressing the human M2 or M4 mAChR. NNC 11-1607 is promising for research of central nervous system disorders, such as Alzheimer’s disease and schizophrenia.
    NNC 11-1607
  • HY-119385
    Savoxepin mesylate 79262-47-8 98%
    Savoxepin mesylate is a D2 dopamine receptor (D2 Dopamine Receptor) antagonist with antipsychotic activity. Savoxepin mesylate selectively blocks dopamine D2 receptors in the hippocampus while having no significant effect on D2 receptors in the striatum. This selective blockade helps reduce the risk of extrapyramidal side effects (EPS).
    Savoxepin mesylate
  • HY-119389
    RGH-1756 207277-37-0 98%
    RGH-1756 is an atypical antipsychotic that has a strong and selective antagonist activity on human D3 and less pronounced activity on human D2L and 5HT1A receptors.
    RGH-1756
  • HY-119509
    Cismethrin 35764-59-1 98%
    Cismethrin is a pyrethroid insecticide that produces Type I effects on intact nerve.
    Cismethrin
  • HY-119772
    VU0366369 1222834-53-8 98%
    VU0366369 (ML137) is a selective positive allosteric modulator (PAM) for mAChR M1 with an EC50 of 830 nM. VU0366369 can be used in research about central nervous system diseases.
    VU0366369
  • HY-119774
    Caroxazone 18464-39-6 98%
    Caroxazone is a reversible inhibitor for monoamine oxidase (MAO). Caroxazone exhibits activity as an antidepressant agent.
    Caroxazone
  • HY-119776
    UBP618 1333110-86-3 98%
    UBP618 is a non-selective N-methyl-D-aspartate inhibitor.
    UBP618
  • HY-119820
    Xaliproden free base 135354-02-8 98%
    Xaliproden (SR57746) free base is an orally active, highly selective 5-HT1A receptor agonist. Xaliproden free base activates pertussis toxin-sensitive G protein-coupled signaling cascades, as well as the PKC, ERK1/ERK2, Akt and p21 Ras/MEK-1 pathways. Xaliproden free base also downregulates the JNK/p66/c-Jun signaling pathway, induces phosphorylation of the shc adaptor protein, regulates extracellular dopamine and 5-HT levels, and induces [35S]GTPγS labeling in rat brain structures rich in 5-HT1A receptors. Xaliproden free base exerts neurotrophic, neuroprotective, renoprotective, anti-inflammatory, anti-apoptotic, anti-fibrotic and analgesic effects. Xaliproden free base also enhances NGF-induced neurite outgrowth, promotes motor neuron survival, attenuates renal tubular injury and inhibits chemotherapy-induced mechanical allodynia, without activating or altering NGF-induced TrkA receptor activation. Xaliproden free base can be used in the research of motor neuron disease, diabetic nephropathy, chemotherapy-induced peripheral neuropathy, amyotrophic lateral sclerosis, Alzheimer's disease, acute tonic nociceptive pain, inflammatory pain, depression and anxiety.
    Xaliproden free base
  • HY-119878
    Lobuprofen 98207-12-6 98%
    Lobuprofen is a potent COX inhibitor. Lobuprofen can be used in study neurological diseases.
    Lobuprofen
Cat. No. Product Name / Synonyms Application Reactivity